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UpHill enables health teams to improve outcomes and streamline care by applying evidence-based knowledge through stepwise clinical pathways.

UpHill Health

UpHill has officially certified its software as a Class IIa medical device

, marking a significant milestone in healthcare technology. 

This achievement places UpHill among the first European software companies to obtain this certification

, reinforcing our leadership in care orchestration and automation fields. Over the past two years, the company has undergone an extensive evaluation process, led by independent international auditors, to ensure compliance with the highest industry standards.

Achieving Class IIa certification is a testament to UpHill’s commitment to delivering safe, reliable, and high-performance technology. The process represented not only a significant financial investment - approximately half a million euros - but also a major effort from the entire team. The certification reflects the company's vision and ongoing commitment to aligning with the highest regulatory standards, reinforcing patient safety and clinical excellence.

, co-founder and CEO of UpHill, emphasizes the significance of this certification:

Class I vs. Class IIa: Understanding the Distinction

In the European Union, medical devices are classified based on the level of risk they pose and the complexity of their function. As software becomes an integral part of modern healthcare, regulatory frameworks now recognize certain digital solutions as medical devices. However, not all software certifications are equal. While many companies opt for Class I certification due to its simpler process, UpHill took the extra step to achieve Class IIa, which involves a much more rigorous evaluation. Here’s what sets our software apart:

2. Complexity and Clinical Impact of Software Features

6. Clinical Validation & Evidence Requirements

8. User Documentation & Safety Information

What Does This Certification Mean for Hospitals?

For hospitals choosing a care orchestration solution, Class IIa certification serves as a crucial decision-making factor, as it guarantees that healthcare providers are investing in cutting-edge technology, independently validated, and designed to ensure maximum patient safety and operational efficiency.

By securing Class IIa certification, UpHill has set a new standard in healthcare software, offering a level of credibility and robustness that few competitors can match. This milestone not only validates UpHill’s technology but also reassures healthcare providers that they are implementing a solution built on the highest safety and quality standards.

UpHill Achieves European Class IIa Medical Device Certification

The imbalance affecting today’s healthcare systems is well known: population needs are growing exponentially, while the capacity to respond remains linear. In this context of limited resources - and with an ever-increasing number of strong clinical guidelines - 

there’s a pressing need to allocate higher-value tasks more intelligently to healthcare professionals

. As such, discussions about the potential of technology for a healthier, more efficient, and more advanced future are only meaningful if the foundation of care delivery is also transformed, f

reeing doctors, nurses, and other professionals to focus on high-value, high-impact tasks

In this article, we specifically focus on optimizing pre-anesthesia assessments. To address the core question, we explore which lower-value tasks can be streamlined or automated.

The problem: inadequate preoperative workup is leading to surgery cancellations but there isn’t a standardized approach to doing it

 are due to inadequate preoperative workup

, and it is well established that preoperative clinics reduce the risk of such cancellations and delays. However, there isn’t a standardized approach to do it.

Likewise, there is currently no standard protocol for determining which patients have Pre-Anesthetic Medical Evaluations (PAMEs),

 as the decision often varies depending on the surgical provider. In some practices, only high-risk patients are referred for a PAME, while others require all patients to complete one. For young, healthy, asymptomatic individuals, these evaluations rarely result in changes to medication or the need for pre-operative testing. Evidence suggests routine laboratory screening tests seldom influence surgical management or improve clinical outcomes. Furthermore, the anesthesia team often conducts its preanaesthetic assessment before surgery, which can lead to duplicate evaluations.

Recently, the COVID-19 pandemic compelled the healthcare system to adopt new practices and expedite the implementation of others that had been progressing gradually. In 2020, this led to the release of the 

Guidelines: Anesthesia in the Context of the COVID-19 Pandemic

using a standardized questionnaire to screen for symptoms of SARS-CoV-2 infection before any surgery

. If this approach was effective during the pandemic, why not apply it universally to all surgeries?

Using a standardized questionnaire enhances the thoroughness of symptom collection and ensures the reproducibility of medical examinations. It is an effective tool for 

gathering accurate information from many patients

The collected data are easily quantifiable and traceable.

 For such a questionnaire to be effective, it must possess key qualities like acceptability, reliability, and validity. The questions should be formulated to be easily understood by the widest range of patients, free of ambiguity, and based on evidence-validated items.

What’s new? Strong recommendation to use 

telemedicine and standardized questionnaires on the preoperative anesthesia assessment.

A new guideline from the European Society of Anaesthesiology and Intensive Care, published a few weeks ago in the European Journal of Anaesthesiology, recommends:

This is a strong recommendation (1B), meaning it should be followed in most cases, as there is a high level of confidence that the benefits outweigh the risks.

According to the authors, various telemedicine applications have been reported to significantly boost scientific output during the COVID-19 pandemic. Although it doesn't allow for a physical examination, telemedicine enables the collection of information before a patient's admission, helping with the screening and triaging of those with suspected or confirmed infections, as well as assessing the severity and progression of their condition. Additionally, telemedicine can help identify patients who need an in-person preoperative evaluation due to multiple comorbidities.

UpHill’s Perioperative Package: reducing

 surgical wait times, preventing cancellations, and ensuring a safe return home

UpHill is a care orchestration software that seamlessly integrates with existing hospital information systems to automate tasks and fill gaps in care. Our 

 is designed to achieve the following goals:

To achieve this, we focus on three key areas:

A future (closer than it seems) where technology frees healthcare teams from low-value tasks

UpHill is thrilled to see these guidelines published, as they perfectly align with the vision our medical team has for optimizing the perioperative process, which is already being implemented in several healthcare institutions.

By using scientifically validated questionnaires and scores to stratify patients based on their surgical and individual risks, we ensure that everyone receives a pre-anesthesia assessment. At the same time, healthcare teams can focus their valuable time on higher-risk patients. 

This approach clearly separates low-value tasks from high-value ones, leading to more efficient and sustainable healthcare systems.

From the patient’s perspective, the benefits are significant

 Patients can provide information about their condition at a time and place that suits them.

his inclusive approach ensures that everyone is assessed, while also eliminating unnecessary in-person appointments, reducing wait times, and allowing healthcare professionals to focus more on complex cases.

 So, to answer the original question: yes, anesthetize safely.

“To anesthetize, or not to anesthetize?” - that is the question

Broadly speaking, all routinely collected data on patient health - outside of controlled clinical trials - are known as Real-World Data (RWD). 

 When we analyze this RWD, we produce real-world evidence (RWE): 

Real-world data have been widely used in research for purposes like tracking drug safety after release and observing patient disease progression over time. With the rapid expansion of healthcare technology—such as electronic systems, biosensors, and mobile and wearable devices—large amounts of RWD are now collected routinely. This wealth of information has immense potential to improve study design and address previously unmet clinical needs.

But could RWD be doing even more? Are there ways to use this information in real-time to improve care rather than only after studies are complete?

Reflecting on UpHill’s participation in the symposium 

, we take a deep dive into how real-world data could be better aligned with the immediate needs of patients, healthcare professionals, and health systems.

To be clear, the value of RWD in assessing a medical product’s benefits in real-world settings is well-documented. The lack of strict eligibility criteria, the ability to track patient behavior in actual healthcare settings, and the potential to support research on high-risk groups - such as pregnant women and children - make it invaluable, especially for research that randomized controlled trials (RCTs) cannot always accommodate.

However, aren’t these approaches working at two very different paces? While RWD may be more cost-effective than an RCT for assessing, for example, the safety of a drug used in heart failure treatment, could this traditional approach fall short of the real impact that the same data could have on managing disease in real-time? Used effectively in day-to-day practice, couldn’t real-world data create a transformative impact on patient care?

Let’s take a step back to address the critical challenge facing healthcare systems worldwide: 

 - driven by an aging population and rising rates of complex chronic diseases - 

while healthcare capacity, regarding available health professionals, remains largely stagnant

. This widening gap leads to familiar issues: long waiting lists for appointments, delays for surgeries, and overcrowded emergency departments.

In this context, healthcare professionals don’t need an overwhelming influx of data that complicates their work;

 they need precise, relevant data to make informed decisions at the right time

. Health systems don’t need to invest in the latest technology for technology’s sake; 

they need to focus on interventions that have demonstrated potential to improve patient outcomes

. And patients don’t need the newest devices on the market; 

they need a healthcare system that’s available when they need it most.

real-world data proves its value when it can influence the course of care for an individual patient while simultaneously streamlining care delivery on a population-wide scale

This journey-based model, fuelled by real-world data, is uniquely equipped to respond to each individual’s unpredictable disease progression, adapting to meet needs as they arise.

A few years ago, while reflecting on the global response to the COVID-19 pandemic, we observed that the future — and increasingly, the present — 

belongs to hybrid models that blend different types of evidence

. Each of them plays a crucial role: scientific evidence should guide care delivery, serving as a map, while real-world data should drive real-time decisions - much like a GPS, offering real-time guidance based on constantly updated information.

This may sound idealistic, but it’s exactly what 

. Believe it or not, all patients need is a mobile phone.

Disclaimer: This article draws on the presentations by Clara Jasmins and Eduardo Freire Rodrigues at the symposium The Impact of RWE on Clinical Pathways.

Real-World Data: can we turn information overload into real-time impact?

Cancer presents as a multifaceted condition, often demanding diverse interventions from numerous healthcare professionals over prolonged periods of time. In one UK study, it was found that patients, who had been treated for cancer for less than a one-year period, saw 28 doctors on average, and the minimum number of doctors met was 13.

 A value that mirrors the intricacy of these journeys and the diverse array of professionals involved, even only considering medical doctors.

On the other hand, time stands as a critical factor in the journey of an oncology patient: every month delayed in cancer treatment can raise risk of death by around 10%.

 Thus, swift, and precise interventions significantly impact prognosis, intensifiyng the pressure to orchestrate timely and well-coordinated care.

The Agency for Healthcare Reasearch and Quality states that: 

Despite the widely acknowledged importance of care coordination in care delivery, and the progress that has been made, achieving this coordination remains an ongoing challenge, especially within oncology journeys, which can manifest in different scopes:

In fact, research indicates that patients, caregivers, and clinicians are extensively engaged in significant 'invisible work' to facilitate care coordination. This invisible work involves spending time navigating system barriers such as non-interoperable medical record systems, inadequate decision support, suboptimal communication systems, and expanding panel sizes. These barriers hinder effective coordination among the network of health systems, clinicians, patients, and caregivers responsible for coordinating care collectively. The costs and benefits of this unseen effort on the quality of life, productivity, and other outcomes for patients, clinicians, and health systems have not been thoroughly quantified, but they are likely unsustainable.

A lack of coordinated care can lead patients getting "lost" in the system and failing to access appropriate services, as well as more unplanned health utilisation.

Intelligent, automated, and evidence-based care journeys guiding care

, we delved into the significance of bridging the gaps within healthcare systems and outlined the crucial prerequisites for accomplishing this feat. It all begins by delineating comprehensive and multidisciplinary care journeys. These tools function akin to a map, interlinking multiple system points and directing the course of care. Ultimately, this works like a multidisciplinary consensus ensuring that every patient receives precisely the right care at every juncture.

Moreover, care journeys foster coordination among various levels of care and healthcare professionals, bridging the gaps that often lead to disjointed care, facilitating seamless transitions between care settings, ensuring that vital information and treatments are consistently communicated and executed.

 is a stepwise multidisciplinary care plan guiding patient progression through a sequence of milestones translated from guidelines or evidence into personalized contexts, allowing decision support and digital automation of clinical activities, and aiming to standardize care and improve patient’s outcomes and experience.

Hence, we are referring to a care orchestration system that integrates decision support tools and communication with automation capabilities. This system uses automation to handle administrative or repetitive clinical tasks, enabling healthcare providers to amplify their efforts and focus on specialized tasks, catering to the intricacies of complex patient needs.

Furthermore, it establishes an accessible channel for engaging with, monitoring, and providing care to patients during intervals between standard care interactions. This system utilizes gathered information to automatically update the patient's journey status and promptly alert healthcare professionals about any warning signs.

Interoperable and robust technology ensuring patient traceability

When discussing the necessity of care coordination, it is unavoidable to recall the four levels of care integration outlined by the Nuffield Trust.

Once again, despite noteworthy efforts, a report by the European Commission

 highlights that an interoperable Electronic Health Record (EHR) is not widespread in most of the studied systems. Many patients face challenges in accessing and utilizing their data or transferring it between healthcare providers. The prevalence of interoperable systems between regions or entire countries is not substantial.

Moreover, more critical issues persist regarding service and clinical integration. There is a scarcity of integrated, multidisciplinary, and comprehensive care journeys in place, and the referral criteria lack clarity, leading to disconnected care levels. Additionally, accessing structured health information that is compiled and updated in real-time based on each patient's pathway evolution remains a challenge.

That is why stressing the importance of interoperability in care orchestration software is crucial for optimizing healthcare delivery, namely cancer journeys. Interoperability, like HL7, acts as the bridge, facilitating smooth communication and data exchange among diverse healthcare information systems. In an environment where information is spread across various platforms, interoperability ensures that essential patient data moves effortlessly between systems, promoting teamwork among healthcare professionals. This interconnected system not only simplifies procedures but also improves the precision and speed of decision-making, leading to better patient care.

Key benefits of UpHill’s approach to coordinate oncology journeys

Enhancing oncology: automating the invisible work

Throughout UpHill’s history, there has been a common denominator: each year surpasses what we had planned for. This is a function of our work — our unique collective force —, as it is a function of how humanity really needs what we are building.

These two elements serve as the key contributors that have brought us to this moment when 

we joyously celebrate our Series A funding round

. Following a remarkable year that showcased 

UpHill's capacity to deliver journey-based care that enhances healthcare capacity and elevates patient outcomes

, and launching Liber — an innovative digital service poised to transform the healthcare landscape — we stand ready to embark on the next chapter by scaling our impact through journey-based care.

Our solid journey to increase healthcare access at scale, steered by evidence, and in compliance with industry standards.

UpHill was founded in 2015 with a clear mission: 

to empower people to provide and receive the best care

. This mission has taken several shapes and, fast forward to today, UpHill stands out as

 the most highly invested care orchestration company in the European Union

. A milestone that attests to the robustness, safety, and efficacy of our technology, as well as our clinical knowledge, setting us apart from other players.

UpHill improves lives with care orchestration software that works both for healthcare teams and patients. During a turbulent period, when the healthcare system grappled with significant challenges in meeting population needs, UpHill was established as the “second brain” behind care provision within major institutions.

Together with the pioneering, dedicated, and talented frontline teams, we are successful in designing, implementing, and delivering novel journeys for the most challenging conditions.

The impact of what we have done together is refreshing:

Throughout our journey, we've come to understand that issues impacting healthcare institutions, such as growing demand and insufficient capacity, are often tied to lacking alternatives that enable individuals to avoid using these services for all and every reason. In essence, healthcare systems are marked by uneven participation from both healthcare professionals and patients.

Healthcare professionals shoulder a heavy load, from diagnosing and treating acute illnesses to managing daily administrative tasks, preventing diseases, and overseeing chronic conditions. Conversely, in most cases, patients find themselves detached from their care journey, lacking information, and without the necessary tools to proactively engage in health promotion, prevention, and disease management.

This is why in 2023 we invented the next-generation care model: 

Liber provides better care, faster, and at a lower price. Liber members can quickly solve acute health issues by interacting immediately with Liber doctors, and enrolling in disease prevention and health promotion programs. All happens at the pace of a high-tech, premium, and personalized service running on the UpHill platform, which accelerates both members and doctors, building on structured medical knowledge.

As I am writing this, people are still awaiting help for hours long in crowded hospitals and primary care centers. From here across the globe, those in need have to wait years for surgeries, many months for appointments, and too many hours for acute care. This is unbearable. This is why UpHill exists, and this is why we are just getting started: our platform is the care orchestration software for the decades to come.

As we continue to solidify our presence in the Iberian market, 

UpHill is set to expand its footprint by opening offices in new locations such as UK and Spain.

With plans to double our team by the end of the year

we are on the hunt for the most talented people with a drive to change healthcare globally

we are in the business of improving life. 

We believe every patient must be on a well-defined, high-quality care journey.

A journey that augments healthcare workers' capacity, enables people’s self-efficacy, and streamlines healthcare systems coordination.

This is how we will achieve access to high-quality care at scale.

UpHill raises €7M to scale journey-based care

Transcribing clinical records by voice, paperless prescriptions, automated scheduling, automatic assistants monitoring patients, or even robotic surgery is not science fiction. There are numerous examples of how technology redesigns the way healthcare reaches, interacts, and treats citizens throughout a relationship that is increasingly continuous, proactive, close, and secure.

One could say that patient-centred care is the way to go. But we at UpHill prefer to think about 

. Why? Because patient-driven care extends beyond placing the patient at the centre of healthcare decision-making and tailoring services to their unique needs. It means dynamically using real-time patient information to adapt and refine each individual's healthcare journey. This approach involves actively and safely leveraging the data received from patients to continuously adjust and optimize their ongoing care, ensuring that every step of the process aligns precisely with their evolving needs, preferences, and values.

The good news is that we now have the tools to make it happen.

Empowering patients with a personalized care journey...

 play a pivotal role in modern healthcare by offering a structured roadmap that guides patients’ care. Standardizing best practices within these care journeys ensures consistency and quality in healthcare delivery, no matter where the patient is. By mapping the ideal path for specific conditions or treatments, healthcare providers can streamline processes, reduce errors, and enhance overall patient outcomes.

Moreover, these journeys foster coordination among various levels of care and healthcare professionals, bridging the gaps that often lead to disjointed care approaches, resulting in suboptimal outcomes and increased healthcare costs. Care journeys serve as a cohesive thread, weaving the different facets of care into a unified narrative. They facilitate seamless transitions between care settings, ensuring that vital information and treatments are consistently communicated and executed.

… and increasing healthcare professionals' efficiency…

 working together with clinical pathways, we have the “best of both worlds”: the scientific knowledge to define processes and the technology to streamline them. 

Care orchestration software combines decision support tools – providing healthcare professionals with a real-time roadmap to ensure standardized and evidence-based care delivery – and communication and automation capabilities – leveraging automation to handle administrative or repetitive tasks and empowering healthcare providers to optimize their efforts and focus on differentiated tasks and more complex patient needs.

The greatest strength lies in the care orchestration solutions' ability to reduce care fragmentation through resolutive digital interactions, providing an open channel for engaging, monitoring, and treating patients between standard care interactions. These systems aid healthcare professionals in 

 actions and attention to patients requiring immediate care or heightened support.

Through comprehensive patient tracking, these technologies enable a panoramic view of each patient’s journey, fostering a proactive approach to healthcare delivery where personalized care is streamlined and resources are allocated effectively to those in most need.

… through interoperable and robust technology.

 capabilities in a care orchestration software is paramount in optimizing healthcare delivery. Interoperability, such as HL7, acts as the connective tissue, enabling seamless communication and data exchange across various healthcare systems. In a landscape where information is scattered across different platforms, interoperability ensures that pertinent patient data flows effortlessly between systems, fostering collaboration among health teams. This interoperable framework not only streamlines processes but also enhances the accuracy and timeliness of decision-making, ultimately resulting in improved patient care. Interoperability is pivotal for creating a unified and efficient healthcare ecosystem, where information is fluid, and collaboration is seamless.

Care orchestration software’s must-haves to promote patient-driven care.

In addition to mapping care journeys, integrating a decision support system, and automating actions, there are other critical features to consider when choosing software in order to ensure a patient-driven approach. A software that allows:

Digitalization strengthening humanization.

The shift towards patient-driven healthcare empowers individuals to actively manage their well-being through a digital connection that bridges the gap between patients and their care, ultimately improving patient outcomes.

Embracing digital health balances healthcare systems, enhancing patient resolution while minimizing resource utilization. It also reshapes the doctor-patient relationship into a continuous through a digitally facilitated connection. 

Embracing digital health balances healthcare systems, enhancing patient resolution while minimizing resource utilization

. It also reshapes the doctor-patient relationship into a continuous through a digitally facilitated connection. As healthcare professionals leverage technology to handle tasks, they are more available to listen, think, and treat their patients, moving from executors to decision-makers and managers.

 this evolving doctor-patient relationship does not lessen the humanity in healthcare. It intensifies it

. Technology, especially automation, allows healthcare professionals to focus on what truly matters: their patients. 

It empowers them to establish profound connections, emphasizing the patient's significance in the healthcare narrative

 Embracing the humanization era in healthcare

Intelligent Implementations of the European Electronic Health Record Exchange Format (EEHRxF)

The Consortium at a Glance

i2X is on a mission to enhance patient care by making health data more comprehensive, accessible, and structured, while empowering patients to share information seamlessly with clinicians and take a more active role in their healthcare. This approach promotes continuity in cross-border care.

Unlocking high quality, coordinated care across borders

i2X is boosting efficiency and reducingcosts by streamlining data exchange across healthcare organizations. By aligning with EEHRxF standards, i2X aims to achieve interoperability across more than 50% of healthcare services at the regional, national, and EU levels.

Laying the groundwork for EU-scale interoperability

i2X actively engages key stakeholders (such as clinicians, IT vendors, patients, and policymakers) through co-creation, offering practical guidance to support the adoption of EEHRxF in real-world clinical settings. By showcasing sustainable implementation practices, i2X helps build a more standardized and connected EU health data ecosystem.

Building a sustainable EU health data ecosystem

Already available technologies demonstrated in-service

availability of high-quality, structured health data in EHRs 

Creating Impact at Scale

Henrique Martins

The i2X project has launched to establish a Common Format for Electronic Health Records across the EU, marking a major step toward creating the European Health Data Space.



New EU project to connect health data of 3 million citizens

News & Events

Five focus areas to deliver meaningful impact 

From Innovation to Impact: i2X Drives Real-World Implementation

Meet the Partners

Co-funded by the European Union

Intelligent Implementations of the European Electronic Health Record Exchange Format Project: Implementing and demonstrating the value of the EEHRxF in a scalable and sustainable way.